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KMID : 0361720070180040407
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Korean Journal of perinatology
2007 Volume.18 No. 4 p.407 ~ p.414
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Current Trends of the Hyperbilirubinemia and the Results of Auditory Evoked Potential
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Bin Joong-Hyun
Kim So-Young
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Abstract
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Objective : The purpose of this study was to identify current trends of the hyperbilirubinemia and the results of auditory evoked potential and evaluate them for early and late evidence of bilirubin brain injury.
Methods : We reviewed the charts of all neonates who were admitted to the Holy family hospital of CUMC for exclusively neonatal jaundice (between January 2002 and December 2006). The gestational age, age at peak bilirubin level, peak bilirubin level, feeding method and brainstem auditory-evoked potential (AEP) were reviewed.
Results : We identified 121 term and 101 preterm infants admitted to the hospital. The mean peak bilirubin values of term and preterm infants were 22.7±0.5 and 13.7±0.3 mg/dL. The mean age at peak bilirubin level of term and preterm infants were 7.5±0.5 and 4.7±0.2 days. All were breastfed (46.3% vs. 30.7%) or fed a combination of breast and bottle feedings (53.7% vs. 44.5%) in term and preterm infants. Comparison of peak bilirubin levels and age at peak bilirubin level in the serum of term and preterm group and normal and abnormal AEP group in first test showed no significant relationship. Trend in peak serum indirect bilirubin level in term infants ware significantly increased recent 3 years. Trend in AEP abnormality showed no significant changes during the study periods. Only two preterm infant showed abnormal AEP at follow up study.
Conclusion : Recently, increased frequency of breast-feeding, shortened hospital stays, and inconsistent follow-up after hospital discharge may cause increasing occurrence of severe hyperbilirubinemia in healthy preterm and term newborn infants. But it is not clear such early onset hyperbilirubinemia may cause acute bilirubin encephalopathy or permanent brain injury.
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KEYWORD
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Hyperbilirubinemia, Kernicterus, Bilirubin encephalopathy, Brainstem auditory, evoked potential
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